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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AQP4
All Species:
29.7
Human Site:
S316
Identified Species:
54.44
UniProt:
P55087
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55087
NP_001641.1
323
34830
S316
E
K
K
G
K
D
Q
S
G
E
V
L
S
S
V
Chimpanzee
Pan troglodytes
XP_512074
323
34825
S316
E
K
K
G
K
D
Q
S
G
E
V
L
S
S
V
Rhesus Macaque
Macaca mulatta
XP_001097418
323
34819
S316
E
K
K
G
K
D
Q
S
G
E
V
L
S
S
V
Dog
Lupus familis
XP_855456
398
42980
S391
E
K
K
G
K
D
P
S
G
E
V
L
S
S
V
Cat
Felis silvestris
Mouse
Mus musculus
P55088
323
34418
S316
E
K
K
G
K
D
S
S
G
E
V
L
S
S
V
Rat
Rattus norvegicus
P47863
323
34462
S316
E
K
K
G
K
D
S
S
G
E
V
L
S
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505227
324
34855
S317
E
K
K
G
K
E
T
S
S
E
V
L
S
S
V
Chicken
Gallus gallus
P28238
262
27053
Frog
Xenopus laevis
NP_001124421
295
31792
Zebra Danio
Brachydanio rerio
NP_001003749
320
34409
T313
E
K
K
E
R
E
S
T
G
E
V
L
S
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V5Z7
245
25557
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193877
295
31953
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZVX8
278
29482
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
77.6
N.A.
92.8
94.1
N.A.
84.8
38.3
69.9
61.6
N.A.
35.5
N.A.
N.A.
38.7
Protein Similarity:
100
100
99.6
79.4
N.A.
95.3
96.5
N.A.
92.9
55.1
79.2
76.1
N.A.
48.6
N.A.
N.A.
55.1
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
80
0
0
66.6
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
0
0
86.6
N.A.
0
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
47
0
0
0
0
0
0
0
0
0
% D
% Glu:
62
0
0
8
0
16
0
0
0
62
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
54
0
0
0
0
54
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
62
62
0
54
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
62
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
24
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
24
54
8
0
0
0
62
62
0
% S
% Thr:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
62
0
0
0
62
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _